One significant Black-led labor strike in American history was the Brotherhood of Sleeping Car Porters strike, which took place in the 1920s and 1930s. The Brotherhood of Sleeping Car Porters was the first labor union led by African Americans to receive a charter in the American Federation of Labor. The union represented the interests of the Pullman Company's African American porters, who faced low wages, long hours, and discriminatory treatment on the job.

The strike began in 1925 when the porters demanded better pay, shorter hours, and improved working conditions. Under the leadership of A. Philip Randolph, the union organized a successful campaign that ultimately led to the signing of a historic agreement with the Pullman Company in 1937. The agreement resulted in improved wages, reduced working hours, and other benefits for the porters.

The Brotherhood of Sleeping Car Porters strike was a significant milestone in both labor and civil rights history, as it demonstrated the power of collective action and paved the way for future advancements in workplace equality.