One significant Black-led labor strike in Black history was the Brotherhood of Sleeping Car Porters strike in the 1920s. The Brotherhood of Sleeping Car Porters was the first labor organization led by African Americans to receive a charter in the American Federation of Labor (AFL). The porters, who worked on trains operated by the Pullman Company, faced poor working conditions, low wages, and long hours.

In 1925, under the leadership of A. Philip Randolph, the Brotherhood of Sleeping Car Porters demanded better wages, shorter work hours, and improved working conditions. The Pullman Company initially resisted these demands but eventually negotiated with the Brotherhood after a long and difficult struggle.

The strike brought attention to the harsh realities faced by Black workers in the railroad industry and paved the way for improved labor conditions for Black workers in other industries. It also highlighted the importance of organizing and collective action in the fight for workers' rights and equality.